biology : class11 Phosphoglycerate Kinase : Location, Steps, Products, ATP Yield : Glycolysis MCQ Questions and Answers
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Phosphoglycerate Kinase
MCQ questions and answers.
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MCQ Questions
1. Which reaction is directly catalyzed by phosphoglycerate kinase during glycolysis?
A.
3-phosphoglycerate + ATP → 1,3-bisphosphoglycerate + ADP
B.
1,3-bisphosphoglycerate + ADP → 3-phosphoglycerate + ATP
C.
1,3-bisphosphoglycerate + NADH → 3-phosphoglycerate + NAD+
D.
3-phosphoglycerate + inorganic phosphate → 1,3-bisphosphoglycerate
Correct Answer:
1,3-bisphosphoglycerate + ADP → 3-phosphoglycerate + ATP
Explanation:
Phosphoglycerate kinase transfers the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, producing ATP and 3-phosphoglycerate.
2. Phosphoglycerate kinase contributes to ATP formation in glycolysis by which mechanism?
A.
Oxidative phosphorylation through an electron transport chain
B.
Substrate-level phosphorylation using 1,3-bisphosphoglycerate
C.
Photophosphorylation driven by light energy
D.
Direct phosphorylation of glucose using ATP
Correct Answer:
Substrate-level phosphorylation using 1,3-bisphosphoglycerate
Explanation:
The enzyme forms ATP directly by transferring a phosphate from the metabolic intermediate 1,3-bisphosphoglycerate to ADP.
3. If one glucose molecule is metabolized completely through glycolysis, how many ATP molecules are generated specifically by phosphoglycerate kinase?
A.
One ATP molecule
B.
Two ATP molecules
C.
Three ATP molecules
D.
Four ATP molecules
Correct Answer:
Two ATP molecules
Explanation:
Each glucose produces two molecules of 1,3-bisphosphoglycerate, and each undergoes the phosphoglycerate kinase reaction to form one ATP, giving two ATP molecules.
4. Why can phosphoglycerate kinase generate ATP despite transferring phosphate from a metabolic intermediate rather than from free inorganic phosphate?
A.
1,3-bisphosphoglycerate contains a high-energy acyl phosphate bond
B.
3-phosphoglycerate is spontaneously converted into ATP
C.
ADP is oxidized directly to ATP by the enzyme
D.
The enzyme obtains energy from NADH oxidation during the reaction
Correct Answer:
1,3-bisphosphoglycerate contains a high-energy acyl phosphate bond
Explanation:
The high phosphoryl-transfer potential of the acyl phosphate bond in 1,3-bisphosphoglycerate drives ATP formation from ADP.
5. Which statement correctly describes the position of the phosphoglycerate kinase reaction in glycolysis?
A.
It is the first ATP-consuming reaction
B.
It is the first ATP-generating reaction
C.
It is the final ATP-generating reaction
D.
It occurs after pyruvate formation
Correct Answer:
It is the first ATP-generating reaction
Explanation:
Phosphoglycerate kinase catalyzes the first ATP-producing step of glycolysis, converting 1,3-bisphosphoglycerate to 3-phosphoglycerate.
6. A deficiency in phosphoglycerate kinase would most directly impair which conversion in glycolysis?
A.
Glucose to glucose-6-phosphate
B.
Fructose-6-phosphate to fructose-1,6-bisphosphate
C.
1,3-bisphosphoglycerate to 3-phosphoglycerate
D.
Phosphoenolpyruvate to pyruvate
Correct Answer:
1,3-bisphosphoglycerate to 3-phosphoglycerate
Explanation:
Phosphoglycerate kinase specifically catalyzes the conversion of 1,3-bisphosphoglycerate into 3-phosphoglycerate while generating ATP.
7. When phosphoglycerate kinase acts on both 1,3-bisphosphoglycerate molecules formed from one glucose molecule, what is the combined stoichiometric result?
A.
Two 3-phosphoglycerate molecules and two ATP molecules
B.
Two 1,3-bisphosphoglycerate molecules and two ATP molecules
C.
One 3-phosphoglycerate molecule and four ATP molecules
D.
Four 3-phosphoglycerate molecules and one ATP molecule
Correct Answer:
Two 3-phosphoglycerate molecules and two ATP molecules
Explanation:
One glucose gives rise to two molecules of 1,3-bisphosphoglycerate, and each enzyme reaction produces one 3-phosphoglycerate and one ATP.
8. Which pair correctly identifies the phosphate donor and phosphate acceptor in the phosphoglycerate kinase reaction?
A.
ATP is the donor and glucose is the acceptor
B.
1,3-Bisphosphoglycerate is the donor and ADP is the acceptor
C.
Inorganic phosphate is the donor and NADP+ is the acceptor
D.
3-Phosphoglycerate is the donor and ATP is the acceptor
Correct Answer:
1,3-Bisphosphoglycerate is the donor and ADP is the acceptor
Explanation:
The enzyme transfers a phosphate group from 1,3-bisphosphoglycerate to ADP, thereby producing ATP.
9. Under standard glycolytic conditions, which change is expected immediately when phosphoglycerate kinase activity is blocked?
A.
ATP formation from 1,3-bisphosphoglycerate decreases
B.
ATP consumption during glucose phosphorylation increases directly
C.
1,3-Bisphosphoglycerate is immediately converted into pyruvate
D.
ADP is converted into NADH by the blocked enzyme
Correct Answer:
ATP formation from 1,3-bisphosphoglycerate decreases
Explanation:
Blocking phosphoglycerate kinase prevents phosphate transfer from 1,3-bisphosphoglycerate to ADP, directly reducing ATP production at this step.
10. Which feature distinguishes the phosphoglycerate kinase reaction from an ATP-investment step of glycolysis?
A.
It uses ATP to attach phosphate to glucose
B.
It produces ATP while converting a phosphorylated intermediate into a lower-phosphate product
C.
It removes both phosphate groups from 1,3-bisphosphoglycerate without forming ATP
D.
It produces NADH instead of ATP from an unphosphorylated substrate
Correct Answer:
It produces ATP while converting a phosphorylated intermediate into a lower-phosphate product
Explanation:
Phosphoglycerate kinase is an ATP-generating step: 1,3-bisphosphoglycerate loses one phosphate as 3-phosphoglycerate forms, and ADP receives that phosphate to become ATP.
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