Six-Carbon Cleavage MCQ Questions and Answers
1. Which six-carbon compound is cleaved during the six-carbon cleavage step of glycolysis?
A. Glucose
B. Fructose-6-phosphate
C. Fructose-1,6-bisphosphate
D. Pyruvate
Correct Answer:
Fructose-1,6-bisphosphate
Explanation:
Fructose-1,6-bisphosphate is the six-carbon molecule that is split during this step of glycolysis.
2. How many three-carbon molecules are formed when fructose-1,6-bisphosphate is cleaved?
A. One
B. Two
C. Three
D. Four
Correct Answer:
Two
Explanation:
The six-carbon fructose-1,6-bisphosphate molecule is divided into two three-carbon molecules.
3. Which enzyme catalyzes the cleavage of fructose-1,6-bisphosphate in glycolysis?
A. Hexokinase
B. Phosphofructokinase
C. Aldolase
D. Pyruvate kinase
Correct Answer:
Aldolase
Explanation:
Aldolase catalyzes the splitting of fructose-1,6-bisphosphate into two three-carbon products.
4. Which pair of three-carbon molecules is produced by the cleavage of fructose-1,6-bisphosphate?
A. Two molecules of pyruvate
B. Glyceraldehyde-3-phosphate and dihydroxyacetone phosphate
C. Glucose-6-phosphate and fructose-6-phosphate
D. Two molecules of acetyl-CoA
Correct Answer:
Glyceraldehyde-3-phosphate and dihydroxyacetone phosphate
Explanation:
Aldolase splits the six-carbon substrate into glyceraldehyde-3-phosphate and dihydroxyacetone phosphate, both of which contain three carbons.
5. What is the carbon number of each product formed during six-carbon cleavage in glycolysis?
A. Two carbons
B. Three carbons
C. Four carbons
D. Six carbons
Correct Answer:
Three carbons
Explanation:
The six-carbon substrate is divided into two molecules, each containing three carbon atoms.
6. Which product of six-carbon cleavage directly continues through glycolysis without first being converted into another three-carbon intermediate?
A. Glyceraldehyde-3-phosphate
B. Dihydroxyacetone phosphate
C. Fructose-1,6-bisphosphate
D. Glucose
Correct Answer:
Glyceraldehyde-3-phosphate
Explanation:
Glyceraldehyde-3-phosphate proceeds directly to the next stage, whereas dihydroxyacetone phosphate is converted into glyceraldehyde-3-phosphate.
7. Dihydroxyacetone phosphate formed during six-carbon cleavage is converted into which molecule?
A. Glucose-6-phosphate
B. Glyceraldehyde-3-phosphate
C. Pyruvate
D. Fructose-6-phosphate
Correct Answer:
Glyceraldehyde-3-phosphate
Explanation:
Dihydroxyacetone phosphate is rearranged into glyceraldehyde-3-phosphate so that both three-carbon products can continue in glycolysis.
8. The six-carbon cleavage step changes one six-carbon molecule into how many total three-carbon molecules available for later glycolytic reactions?
A. One
B. Two
C. Four
D. Six
Correct Answer:
Two
Explanation:
The cleavage produces two three-carbon molecules from one six-carbon fructose-1,6-bisphosphate molecule.
9. Which statement correctly describes the six-carbon cleavage step of glycolysis?
A. A three-carbon molecule combines with another three-carbon molecule.
B. A six-carbon molecule is split into two three-carbon molecules.
C. A six-carbon molecule is converted directly into a two-carbon molecule.
D. Two six-carbon molecules combine to form one three-carbon molecule.
Correct Answer:
A six-carbon molecule is split into two three-carbon molecules.
Explanation:
The defining event of six-carbon cleavage is the aldolase-catalyzed division of fructose-1,6-bisphosphate into two three-carbon compounds.
10. Which of the following is NOT a product of the six-carbon cleavage of fructose-1,6-bisphosphate?
A. Glyceraldehyde-3-phosphate
B. Dihydroxyacetone phosphate
C. Pyruvate
D. Two three-carbon intermediates
Correct Answer:
Pyruvate
Explanation:
The cleavage produces glyceraldehyde-3-phosphate and dihydroxyacetone phosphate. Pyruvate is formed later in glycolysis, not during six-carbon cleavage.
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